Structural Determinants of μ-Opioid Receptor Antagonism and Respiratory Liability in Phenylfentanyl Analogues
did not induce respiratory depression at the tested dose, indicating a lack of intrinsic respiratory liability. These findings delineate structural features governing MOR antagonism and respiratory effects within a fentanyl-derived scaffold.
Authors
- Ahmed Reda
- Rui Lyu (ORCID: https://orcid.org/0009-0005-5308-8071)
- Balaji S. Kale (ORCID: https://orcid.org/0000-0002-5049-5895)
- Piyusha P. Pagare (ORCID: https://orcid.org/0000-0002-4848-2673)
- Y Zhang
- William L. Dewey (ORCID: https://orcid.org/0000-0002-3907-8855)
- E.P. Li
- Neha Upadhyay
- Abeje A. Silte (ORCID: https://orcid.org/0000-0002-7312-0818)
- Logan T Neel
- Huiqun Wang
Institutions
- Virginia Commonwealth University (US)
Publication Details
- Journal
- ACS Chemical Neuroscience
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acschemneuro.5c00836
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse