Alzheimer's Disease as Longitudinal Regulatory Failure: A Unified Temporal Architecture for Multi-Mechanism Sequencing and Preventive Intervention

Description / Abstract: Clinical translation document presenting a unified temporal architecture for Alzheimer's disease as a longitudinal regulatory failure across ten coupled domains. Identifies four bifurcation points (Aβ clearance crossover, menopause regime shift, CAA trap engagement, BBB collapse), proposes sex-differentiated intervention timing, and maps a longitudinal adaptive intervention methodology from validated developmental services practice. This version is prepared for clinical audience accessibility — domain specialists in preventive neurology, gerontology, and related fields. Companion to the primary SIP-NEURO-LONG-01 record which contains the full theoretical formalism.