Acute oral toxicity evaluation of microencapsulated semi-purified fibrinolytic proteases using a modified OECD 423–aligned design for biotechnological applications
) was estimated to exceed 5000 mg/kg body weight, indicating that the formulation is not classified for acute oral toxicity under the Globally Harmonized System. Collectively, these findings indicate no evidence of acute treatment-related toxicological effects under the conditions of this study. Interpretation is limited to single-dose exposure and should be confirmed by further investigations incorporating detailed histopathological and extended toxicity assessments.
Authors
- Nanik Rahmani (ORCID: https://orcid.org/0000-0001-5095-437X)
- Maya Dian Rakhmawatie (ORCID: https://orcid.org/0000-0003-1795-3732)
- Ana Hidayati Mukaromah (ORCID: https://orcid.org/0000-0001-8492-4961)
- Stalis Norma Ethica (ORCID: https://orcid.org/0000-0002-0853-0423)
- Ragil Saptaningtyas (ORCID: https://orcid.org/0000-0003-2545-1353)
- Amin Samiasih (ORCID: https://orcid.org/0000-0002-2482-961X)
- Sri Rejeki
Institutions
- Universitas Muhammadiyah Semarang (ID)
- National Research and Innovation Agency (ID)
Publication Details
- Journal
- Toxicology Mechanisms and Methods
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1080/15376516.2026.2666608
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00