How pharmacokinetic/pharmacodynamic models can inform the development of new HIV medications

There remains a need for new HIV medications. This has been challenged by the increasing costs associated with drug discovery and testing. One solution to this issue involves the incorporation of pharmacokinetic/pharmacodynamic (PK/PD) models into the development pipeline. This article provides an overview of how PK/PD models can be used to provide insights to aid this endeavour. This article is part of the Theo Murphy meeting issue 'Evaluating anti-infective drugs'.

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Publication Details

Journal
Philosophical Transactions of the Royal Society B Biological Sciences
Published
2026-04-30
DOI
https://doi.org/10.1098/rstb.2024.0342
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
0.00

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article

How pharmacokinetic/pharmacodynamic models can inform the development of new HIV medications

Saye Khoo, Shawn Edgar Miranda
Philosophical Transactions of the Royal Society B Biological Sciences
Antibiotics Pharmacokinetics and Efficacy
article

How pharmacokinetic/pharmacodynamic models can inform the development of new HIV medications

Saye Khoo, Shawn Edgar Miranda
article en

Abstract

There remains a need for new HIV medications. This has been challenged by the increasing costs associated with drug discovery and testing. One solution to this issue involves the incorporation of pharmacokinetic/pharmacodynamic (PK/PD) models into the development pipeline. This article provides an overview of how PK/PD models can be used to provide insights to aid this endeavour. This article is part of the Theo Murphy meeting issue 'Evaluating anti-infective drugs'.

Philosophical Transactions of the Royal Society B Biological SciencesVol. 381(1949)
University of Liverpool (GB)
National Institute for Health and Care Research
Good health and well-being
Openalex Percentile: Top 11%
Antibiotics Pharmacokinetics and Efficacy
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