Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors
R, with no steric hindrance observed, supporting a balanced dual antagonism. These results provide a structural basis for the high-affinity dual antagonism of vornorexant and offer insights for the design of orexin receptor antagonists.
Authors
- Chiemi Mishima-Tsumagari
- Masashi Mima (ORCID: https://orcid.org/0000-0003-2336-9129)
- Kunihiko Iwamoto
- Ryo Iwaoka
- Mayumi Sakata-Sakuta
Institutions
- Taisho Pharmaceutical (Japan) (JP)
Publication Details
- Journal
- Acta Crystallographica Section F Structural Biology Communications
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1107/s2053230x26003432
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00