Synergistic effects of halo-plaque forming phage cocktails against polymicrobial <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i>
may promote the release of putative depolymerases and/or cell wall hydrolases that could potentially contribute to matrix degradation; however, further investigation is required to elucidate the precise mechanisms and enzymatic functions involved. Together, these findings would pave the way for advancing halo-forming phages and support the targeted engineering of tail fiber or spike proteins for therapeutic applications in multidrug-resistant polymicrobial infections.
Authors
- Ruttayaporn Ngasaman (ORCID: https://orcid.org/0000-0003-0000-6018)
- Wanna Sudhikaran
- Kamonnut Singkhamanan (ORCID: https://orcid.org/0000-0002-0063-7787)
- Ampapan Naknaen (ORCID: https://orcid.org/0000-0002-5566-1207)
- Arnon Chukamnerd (ORCID: https://orcid.org/0000-0001-6999-5534)
- Sarunyou Chusri (ORCID: https://orcid.org/0000-0002-3116-2518)
- Sanicha Chumtong
- Rattanaruji Pomwised
- Arrita Rueangrit
- Komwit Surachat (ORCID: https://orcid.org/0000-0001-7793-7561)
Institutions
- Prince of Songkla University (TH)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1128/spectrum.04009-25
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Faculty of Medicine, Prince of Songkla University