Renal Tubule Cell-Specific <i>Npr1</i> is Essential to Regulate Blood Pressure and Kidney Dysfunction

BACKGROUND: (encoding NPRA) on blood pressure and renal hemodynamics. METHODS: mRNA or protein. RESULTS: in RT segments significantly increased systolic blood pressure and mean arterial pressure in a sex-specific manner. Mutant male mice showed higher total urinary protein and albumin-creatinine ratios than female mice. On a high-salt diet, male knockout and HT mice showed greater salt sensitivity than female mice. CONCLUSIONS: along the nephron tubules leads to arterial hypertension and abnormal renal functional hemodynamic changes that are more pronounced in male mice compared with female mice.