Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models

resulted in brain exposure sufficient to alter gene expression and reduce IL-1β levels as pharmacodynamic markers of microglial activation and neuroinflammation in an amyloidosis mouse model of Alzheimer's disease.

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Publication Details

Journal
Journal of Medicinal Chemistry
Published
2026-04-30
DOI
https://doi.org/10.1021/acs.jmedchem.6c00010
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models

Alan D. Palkowitz, Andrew D. Mesecar, Philip A. Hipskind, Daniel E. Beck et al.
Journal of Medicinal Chemistry
Alzheimer's disease research and treatments
article

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models

Alan D. Palkowitz, Andrew D. Mesecar, Philip A. Hipskind, Daniel E. Beck, Kratika Singhal, Suzanne Doolen, Disha Soni, Hasi Huhe, Sara K. Quinney, Travis S. Johnson, Steven P. Angus, Mustapha Moussaif, Cynthia D. Jesudason, Ryan D. Imhoff, Shaoyou Chu, Matilda van Buuren-Milne, Stacey J Sukoff Rizzo, Isaac Caballero-Floran, Sean-Paul Williams, Juliane C David, Colin J Beach, Rima Kaddurah-Daouk, Alexandra N Faulkner, Bruce T Lamb, June Javens-Wolfe, Adrian L Oblak, Timothy I Richardson, Lais Da Silva, W Brent Clayton, Emily R Mason, Peter J Meikle, Adam K Hamdani, Jeffrey L Dage, Claudia Rangel-Barajas, Kevin Huynh
article en

Abstract

resulted in brain exposure sufficient to alter gene expression and reduce IL-1β levels as pharmacodynamic markers of microglial activation and neuroinflammation in an amyloidosis mouse model of Alzheimer's disease.

Journal of Medicinal Chemistry
Allen Institute for Brain Science (US), Baker Heart and Diabetes Institute (AU), University of Pittsburgh (US), Duke University (US), Neurosciences Institute (US), La Trobe University (AU), Purdue University West Lafayette (US), Indiana Biosciences Research Institute (US), University School (US), Indiana University School of Medicine, Indiana University (US)
Alzheimer's Drug Discovery Foundation, National Health and Medical Research Council, National Institute on Aging, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 11%
Alzheimer's disease research and treatments
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