Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models
resulted in brain exposure sufficient to alter gene expression and reduce IL-1β levels as pharmacodynamic markers of microglial activation and neuroinflammation in an amyloidosis mouse model of Alzheimer's disease.
Authors
- Alan D. Palkowitz
- Andrew D. Mesecar (ORCID: https://orcid.org/0000-0002-1241-2577)
- Philip A. Hipskind
- Daniel E. Beck
- Kratika Singhal (ORCID: https://orcid.org/0000-0002-5695-743X)
- Suzanne Doolen (ORCID: https://orcid.org/0000-0003-1843-7510)
- Disha Soni
- Hasi Huhe
- Sara K. Quinney (ORCID: https://orcid.org/0000-0002-6554-0695)
- Travis S. Johnson (ORCID: https://orcid.org/0000-0002-4628-2256)
- Steven P. Angus (ORCID: https://orcid.org/0000-0002-7655-657X)
- Mustapha Moussaif
- Cynthia D. Jesudason
- Ryan D. Imhoff (ORCID: https://orcid.org/0000-0002-8510-8437)
- Shaoyou Chu
- Matilda van Buuren-Milne
- Stacey J Sukoff Rizzo
- Isaac Caballero-Floran
- Sean-Paul Williams
- Juliane C David
- Colin J Beach
- Rima Kaddurah-Daouk
- Alexandra N Faulkner
- Bruce T Lamb
- June Javens-Wolfe
- Adrian L Oblak
- Timothy I Richardson
- Lais Da Silva
- W Brent Clayton
- Emily R Mason
- Peter J Meikle
- Adam K Hamdani
- Jeffrey L Dage
- Claudia Rangel-Barajas
- Kevin Huynh
Institutions
- Allen Institute for Brain Science (US)
- Baker Heart and Diabetes Institute (AU)
- University of Pittsburgh (US)
- Duke University (US)
- Neurosciences Institute (US)
- La Trobe University (AU)
- Purdue University West Lafayette (US)
- Indiana Biosciences Research Institute (US)
- University School (US)
- Indiana University School of Medicine
- Indiana University (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00010
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Drug Discovery Foundation
- National Health and Medical Research Council
- National Institute on Aging
- National Cancer Institute