Proarrhythmic Risk Assessment of Sildenafil under High-Dose Misuse Conditions Using the Comprehensive In Vitro Proarrhythmia Assay (CiPA)
. Despite low in silico TdP predictions, functional assays suggest that high concentrations of sildenafil as in misuse may pose a clinically relevant risk of QT prolongation and arrhythmia.
Authors
- Minji Kang (ORCID: https://orcid.org/0000-0003-2930-4780)
- Chan Hyeok Kwon (ORCID: https://orcid.org/0000-0001-7338-2538)
- Sujeong Park (ORCID: https://orcid.org/0000-0001-6163-8962)
- Tae Woong Na (ORCID: https://orcid.org/0000-0003-4003-083X)
- Kikyung Jung
- Inkyo Jung
- Hanbi Kim
Institutions
- Ministry of Food and Drug Safety (KR)
Publication Details
- Journal
- Biomolecules & Therapeutics
- Published
- 2026-04-30
- DOI
- https://doi.org/10.4062/biomolther.2025.097
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Food and Drug Safety