Low-dose simulated galactic cosmic radiation exposure after hindlimb unloading has long-term impact on skeletal muscle metabolic proteins in female mice
Acute simGCRsim exposure causes changes in metabolic and mitochondrial protein abundance that are observable after 9 mo. Weight-bearing and unloaded muscle show unique metabolic protein profiles, with unloaded muscle experiencing reduced expression of glycolytic proteins relative to weight-bearing muscle after 9 mo. Significant dose-dependent response to acute simGCRsim exposure, with higher doses having more profound effects on metabolic and antioxidant protein abundance.
Authors
- Guillaume Spielmann (ORCID: https://orcid.org/0000-0001-7024-0972)
- Matthew M. Robinson (ORCID: https://orcid.org/0000-0001-7622-7357)
- Jeffery C. Chancellor (ORCID: https://orcid.org/0000-0003-0735-0137)
- Matthew Martone
- Brian A. Irving (ORCID: https://orcid.org/0000-0002-4131-9523)
- Neil M. Johannsen (ORCID: https://orcid.org/0000-0003-4905-4491)
- Heather C M Allaway
Institutions
- Pennington Biomedical Research Center (US)
- Louisiana State University (US)
- Oregon State University (US)
- University of British Columbia (CA)
- Mitchell Institute (US)
- SUNY Plattsburgh (US)
- Texas A&M University (US)
Publication Details
- Journal
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1152/ajpregu.00014.2026
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Aeronautics and Space Administration