KSHV Genome in Saliva, Whole Blood and Kaposi's Sarcoma Biopsy Specimens in Republic of Congo: Phylogenetic Analysis and an APOBEC3B Mutational Signature
cells. NGS allowed us to have 8 full sequences out of the 15 samples analyzed. Phylogenetic analysis on KSHV-whole-genome resulted in distinct phylogenetic clustering between the genomic sequences of Congolese KSHV and those derived from Western countries. KSHV ORF-K1 subtypes A5, B and C were identified. On KSHV ORF-K15, only the P subtype was observed. We found virtually no APOBEC3B-induced mutations in KSHV genome. KSHV sequences from Congo samples present phylogenetic particularities but remain close to the whole genome sequences found in Sub-Saharan Africa. We were able to observe, using bioinformatics tools, only very few mutations due to APOBEC3B on KSHV genome.
Authors
- Juthèce Private Malanda-Kiminou (ORCID: https://orcid.org/0000-0002-3594-1228)
- Ferdinand Emaniel Brel GOT (ORCID: https://orcid.org/0000-0003-0866-9473)
- Vincent Cálvez (ORCID: https://orcid.org/0009-0002-6855-3472)
- Anne‐Geneviève Marcelin (ORCID: https://orcid.org/0000-0003-4808-8999)
- Gervillien Arnold Malonga (ORCID: https://orcid.org/0000-0003-1840-951X)
- Patrina Joseph Iloukou Mayakia (ORCID: https://orcid.org/0000-0002-5505-2145)
- Aude Jary (ORCID: https://orcid.org/0000-0002-1952-6729)
- Dimitry Moudiongui Mboungou Malanda
- Fabien Mouamba
- Antoine Fauchois
- Jean Félix Peko
- Valentin Leducq
Institutions
- Inserm (FR)
- Sorbonne Université (FR)
- Centre Hospitalier et Universitaire de Brazzaville (CG)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Marien Ngouabi University (CG)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1002/jmv.70933
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00