Organocatalytic Enantioselective Aza-Michael Addition of <i>N</i> -Methoxyamides to <i>α,β</i> -Unsaturated Aldehydes
-amino carbonyl compounds with up to 97% ee in good to excellent yields. The resulting aza-Michael adducts can be readily transformed into 1,3-amino alcohols and 3,6-disubstituted 2-piperidones, which are valuable pharmacophores in medicinal chemistry.
Authors
- Chanhyun Jung
- Jae Sang Han
- Subramaniyan Prasanna Kumari
- Jae‐Kyung Jung (ORCID: https://orcid.org/0000-0002-0490-9663)
- Hyeju Jo
- Jaeuk Sim
- Bang Yeon Hwang
- Young Hee Lee
- Kwanghee Lee
Institutions
- Chungbuk National University (KR)
- American Association of Colleges of Pharmacy (US)
- Samjin Pharm (South Korea) (KR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.joc.5c02971
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education
- National Research Foundation of Korea