A Longitudinal Comprehensive Biospecimen and Clinical Data Repository for Cancer Early Detection: The InAdvance Study
BACKGROUND: The InAdvance Study addresses the critical need for comprehensive data and biospecimen collection from individuals at elevated risk for cancer. Despite the existence of numerous biobanks in patients with cancer and individuals at average risk for cancer, a gap persists in resources targeting individuals with an elevated risk for cancer. METHODS: The InAdvance Study is longitudinally collecting biospecimens and health data from individuals with a range of cancer risk factors to facilitate collaborative research in cancer early detection and interception. Patient populations include those with pre-cancerous or precursor lesions (e.g. oral precursor lesions, Barrett's esophagus), hereditary cancer risk, personal or family history of cancer, or a history of exposures associated with cancer risk. Additionally, we are enrolling patients receiving multi-cancer early detection (MCED) tests, family members of elevated risk participants, and controls. Key goals include optimized biospecimen collection through standardized procedures, participant enrollment and engagement through an online platform, and standardized scalable procedures. Data is compiled into a central repository, and researchers can request access through a streamlined data request process. RESULTS: Since April 2023, 1,415 participants have enrolled in the study. 817 (58%) completed the baseline survey and 816 (58%) gave a baseline blood sample. CONCLUSION: The InAdvance Study's comprehensive approach provides a framework for basic, population, and translational studies to elucidate the molecular and environmental factors that drive cancer development. IMPACT: Comprehensive data and biospecimen biorepositories are critical to inform strategies for early detection, risk stratification, early interception for risk mitigation, and improved outcomes for higher-risk populations.
Authors
- Junne Kamihara (ORCID: https://orcid.org/0000-0002-2852-7387)
- Tia L. Kauffman (ORCID: https://orcid.org/0000-0002-0419-4223)
- Dipanjan Chowdhury (ORCID: https://orcid.org/0000-0001-5645-3752)
- Matthew B.B. Yurgelun (ORCID: https://orcid.org/0000-0002-6184-9273)
- Kevin M. Elias (ORCID: https://orcid.org/0000-0003-1502-5553)
- Tara Berman (ORCID: https://orcid.org/0000-0001-5165-0570)
- Brian D. Crompton (ORCID: https://orcid.org/0000-0001-9404-6621)
- Nicolette J. Rodriguez (ORCID: https://orcid.org/0000-0002-5685-0667)
- Lisa Diller (ORCID: https://orcid.org/0000-0002-4073-5509)
- Jenna B. Beckwith (ORCID: https://orcid.org/0000-0001-7022-2133)
- Colleen M. Feltmate (ORCID: https://orcid.org/0000-0002-7700-8575)
- Ana Babić (ORCID: https://orcid.org/0000-0003-1199-5958)
- Elizabeth A. Mittendorf (ORCID: https://orcid.org/0000-0002-9762-8536)
- Glenn J. Hanna (ORCID: https://orcid.org/0000-0002-9969-2523)
- Sook‐Bin Woo (ORCID: https://orcid.org/0000-0002-6248-2282)
- Sahand Hormoz (ORCID: https://orcid.org/0000-0002-4384-4428)
- Kristen D. Brantley (ORCID: https://orcid.org/0000-0003-0084-4775)
- Jacob M. Sands (ORCID: https://orcid.org/0000-0003-4663-7464)
- Lachelle D. Weeks (ORCID: https://orcid.org/0000-0001-8726-6212)
- Catherine R. Marinac (ORCID: https://orcid.org/0000-0002-9128-3012)
- Bicky Thapa (ORCID: https://orcid.org/0000-0002-7636-8907)
- Elizabeth O’Donnell
- Kareem Adams
- Timothy R Rebbeck
- Giovanni Parmigiani
- Sapna Syngal
- Ann H Partridge
- Narjust Florez
- Irene Ghobrial
- Nicole R Leboeuf
- Judy E Garber
Institutions
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Harvard University Press (US)
- University of Massachusetts Boston (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Harvard Cancer Center (US)
- IIT@Harvard (US)
- Dana-Farber Brigham Cancer Center (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-1684
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00