Triclabendazole disrupts mitochondrial electron transport <i>in vitro</i>
, while other benzimidazoles do not. Similar effects were observed in mitochondria from additional helminths (trematodes, nematodes) and mammalian cells. These findings indicate a shared mode of action and highlight potential safety risks associated with long-term triclabendazole treatment in mammals.
Authors
- Natalie Wiedemar (ORCID: https://orcid.org/0000-0001-9470-4284)
- María Eugenia Ancarola (ORCID: https://orcid.org/0000-0001-6971-7147)
- Pascal Zumstein (ORCID: https://orcid.org/0000-0002-5360-1614)
- Alice Bernal (ORCID: https://orcid.org/0009-0007-5772-3460)
- Trix Zumkehr (ORCID: https://orcid.org/0009-0002-3614-4930)
- Seraina Mühlemann
- Tobias Kämpfer
- Britta Lundström-Stadelmann
Institutions
- University of Bern (CH)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1128/aac.01756-25
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gottfried und Julia Bangerter-Rhyner-Stiftung
- Uniscientia Foundation