Management of lower urinary tract symptoms before prostate cancer radiotherapy: a call for innovative strategies
Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms (LUTS) in aging men. As the incidence of prostate cancer (PCa) increases with age, coexistence of BPO and PCa is a frequent issue. Radical prostatectomy might be considered as the best option for patients presenting with severe obstructive symptoms, allowing to simultaneously treat both diseases. However, not all patients are eligible or prefer surgery, therefore a large number of patients are referred to receive PCa radiotherapy (RT). Preexisting LUTS represent a well-known risk factor to develop severe genito-urinary (GU) toxicity. While improving urinary function before starting irradiation appears to be crucial, the development of new minimally invasive surgical therapies (MIST) for BPH creates new opportunities for treatment personalization in RT patients with LUTS.
Authors
- M. Sibona (ORCID: https://orcid.org/0000-0002-1997-6527)
- Tom Boeken (ORCID: https://orcid.org/0000-0003-2990-5180)
- Matthijs J. V. Scheltema (ORCID: https://orcid.org/0000-0002-9098-9574)
- Charles Dariane (ORCID: https://orcid.org/0000-0002-9573-2938)
- Rui Bernardino (ORCID: https://orcid.org/0000-0001-8076-4550)
- Lorenzo Bianchi
- Jennifer Le Guevelou
- Marcin Miszczyk
- Pawel Rajwa
- Giancarlo Marra
- Veeru Kasivisvanathan
- Andrea Mari
- Julien Anract
- Marc Sapoval
- On behalf of the YAU Prostate Group
Institutions
- Université de Tours (FR)
- Délégation Paris 5 (FR)
- Cleveland Clinic (US)
- Inserm (FR)
- Medical University of Silesia (PL)
- Université Paris Cité (FR)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Sorbonne Paris Cité (FR)
- Comprehensive Cancer Center Vienna (AT)
- Hôpital Cochin (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- St. Antonius Ziekenhuis (NL)
- Hôpital Européen (FR)
- Prostate Cancer Research (GB)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda USL di Bologna (IT)
- Paris Cardiovascular Research Center (FR)
- WSB University (PL)
- University of Florence (IT)
- University College London (GB)
- Medical University of Vienna (AT)
- University of Bologna (IT)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1007/s00345-026-06427-9
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00