Lysosomal Ion Channel TRPML1 Contributes to Neuropathic Pain Associated With Diabetic Peripheral Neuropathy in Mice

ARTICLE HIGHLIGHTS: A lysosomal ion channel, TRPML1, contributes to neuropathic pain associated with diabetic peripheral neuropathy (DPN). TRPML1 of dorsal root ganglion neurons contributes to type 2 DPN pain. Astrocyte TRPML1 contributes to type 1 DPN pain. Lysosomal ion channels may be novel mechanisms and targets for DPN pain.

Authors

H J Wang
Zhi‐Yong Tan (ORCID: https://orcid.org/0000-0001-7696-113X)
Yonghua Ji (ORCID: https://orcid.org/0000-0002-1866-3211)
Zhang Y
Silin Teng
Yuanhong Yang

Institutions

Hebei Medical University (CN)
Affiliated Hospital of Hebei University (CN)
Hebei Mental Health Center (CN)
Hebei University (CN)
Indiana University – Purdue University Indianapolis (US)

Publication Details

Journal: Diabetes
Published: 2026-04-30
DOI: https://doi.org/10.2337/db25-0901
Primary Topic: Calcium signaling and nucleotide metabolism
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Natural Science Foundation of Hebei Province
Congressionally Directed Medical Research Programs

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article

Lysosomal Ion Channel TRPML1 Contributes to Neuropathic Pain Associated With Diabetic Peripheral Neuropathy in Mice

H J Wang, Zhi‐Yong Tan, Yonghua Ji, Zhang Y et al.

Apr 30, 2026

Diabetes

Calcium signaling and nucleotide metabolism

article

Lysosomal Ion Channel TRPML1 Contributes to Neuropathic Pain Associated With Diabetic Peripheral Neuropathy in Mice

H J Wang, Zhi‐Yong Tan, Yonghua Ji, Zhang Y, Silin Teng, Yuanhong Yang

April 30, 2026article en

Abstract

ARTICLE HIGHLIGHTS: A lysosomal ion channel, TRPML1, contributes to neuropathic pain associated with diabetic peripheral neuropathy (DPN). TRPML1 of dorsal root ganglion neurons contributes to type 2 DPN pain. Astrocyte TRPML1 contributes to type 1 DPN pain. Lysosomal ion channels may be novel mechanisms and targets for DPN pain.

Diabetes

Hebei Medical University (CN), Affiliated Hospital of Hebei University (CN), Hebei Mental Health Center (CN), Hebei University (CN), Indiana University – Purdue University Indianapolis (US)

Natural Science Foundation of Hebei Province, Congressionally Directed Medical Research Programs

Good health and well-being

Openalex Percentile: Top 11%

Calcium signaling and nucleotide metabolism

DOI Source OpenAlex

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Lysosomal Ion Channel TRPML1 Contributes to Neuropathic Pain Associated With Diabetic Peripheral Neuropathy in Mice — H J Wang, Zhi‐Yong Tan, et al. · Diabetes (2026) | TGRS Research Map | TGRS