Development of Biphenyl-Substituted Uracil-Based Hydroxamic Acids (UBHAs) as Potent HDAC Inhibitors with Pro-Apoptotic Activity in Leukemia and Prostate Cancer Cells
cell proliferation, enhanced histone and tubulin acetylation, upregulated p21, and downregulated Bcl-2. These findings identify biphenyl-substituted UBHAs as promising therapeutics and probes to dissect HDAC biology.
Authors
- Simona Nanni (ORCID: https://orcid.org/0000-0002-3320-1584)
- Daniela Trisciuoglio (ORCID: https://orcid.org/0000-0002-7007-7914)
- Giulio Bontempi (ORCID: https://orcid.org/0000-0002-8497-9644)
- Antonello Mai (ORCID: https://orcid.org/0000-0001-9176-2382)
- Raffaele Strippoli (ORCID: https://orcid.org/0000-0003-3483-8381)
- Antimo Gioiello (ORCID: https://orcid.org/0000-0003-0240-2006)
- Valentina Farini
- Emanuele Fabbrizi (ORCID: https://orcid.org/0000-0002-3850-7750)
- Donatella Del Bufalo (ORCID: https://orcid.org/0000-0002-3148-6096)
- Fabrizio Casano
- Daniela Passeri (ORCID: https://orcid.org/0000-0002-0736-753X)
- Valeria Pecci (ORCID: https://orcid.org/0000-0001-9170-3593)
- Federica Michetti
- Letizia Corsetti
- Dante Rotili
- Roberto Pellicciari
- Francesco Fiorentino
- Antonella Di Sotto
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Roma Tre University (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Institute of Molecular Biology and Pathology (IT)
- National Cancer Institute (MY)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
- National Research Council (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c02737
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sapienza Università di Roma
- Associazione Italiana per la Ricerca sul Cancro
- Ministero dell'Università e della Ricerca