PRECLINICAL ANTIDIABETIC EVALUATION OF SIDDHAPANCHANANA RASA IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Background: Siddhapanchanana Rasa is a traditional Ayurvedic medicine for diabetes (Prameha). It contains Sudda Parada, Shudda Gandhaka, Shudda Tankana and herbs like Triphala and Trikatu, Musha,. This study tested if it works against diabetes in rats, comparing it to glibenclamide. Methods: We used 24 rats divided into 4 groups of 6. One group was normal, one got diabetes drug only, one got glibenclamide, and one got Siddhapanchanana Rasa. Diabetes was made with Streptozotocin injection. Treatment lasted 28 days. We measured blood sugar weekly, checked blood fats, body weight, organ weight, and looked at pancreas and liver under microscope. Results: Siddhapanchanana Rasa lowered blood sugar by 29% (250 vs 361 mg/dL in diabetic group). Glibenclamide worked better (56% drop). Both medicines fixed cholesterol (84 vs 131 mg/dL) and fat levels equally well. Siddhapanchanana Rasa also helped control weight gain and protected pancreas and liver. Microscope showed less damage in treated groups. Conclusion: Siddhapanchanana Rasa shows good promise for diabetes treatment. It controls blood sugar decently and works very well for cholesterol and organ protection. More human studies needed.