Immunological mechanism behind reactivated cryptococcosis in persistently infected mice following FTY720 treatment
Tem cells and impairing Th1-mediated immunity. Given the rising use of FTY720, our study highlights its potential risk in patients with subclinical cryptococcosis and underscores the need for preventive strategies to avert disease progression.
Authors
- Hiromasa Tanno (ORCID: https://orcid.org/0000-0002-6031-6432)
- Tetsuji Aoyagi (ORCID: https://orcid.org/0000-0001-6821-9701)
- Hayato Sato (ORCID: https://orcid.org/0000-0003-2599-1229)
- Michiko Yoshida (ORCID: https://orcid.org/0000-0003-4800-8960)
- Nana Nakahata
- Emi Kanno (ORCID: https://orcid.org/0000-0003-2339-122X)
- Ko Sato
- Atsuo Kikuchi
- Keiko Ishii
- Kazuyoshi Kawakami
- Reina Ohagi
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Infection and Immunity
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1128/iai.00612-25
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Chiba University
- Japan Society for the Promotion of Science