Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling
, LIG treatment markedly ameliorated CDDP‑induced lipid peroxidation and ferroptosis in cultured TKPTs via GSK3β inhibition and NRF2 activation. Furthermore, knockout of GSK3β also protected against CDDP‑induced cell death and LIG exerted no additional protective effects in GSK3β‑knockout TKPTs. Together, the present findings offer a new potential strategy for AKI therapies by targeting ferroptosis.
Authors
- Fangfang Cai (ORCID: https://orcid.org/0000-0003-3249-6031)
- Jingyi Sheng (ORCID: https://orcid.org/0000-0001-9008-4874)
- Long Wang (ORCID: https://orcid.org/0009-0009-8788-9116)
- Yongfeng Zhao
- Y F Yang
- Jiayu Song
- Yaru Wang
- Jie Meng
- San Yan Xu
- Juan Lei
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Westlake University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Molecular Medicine
- Published
- 2026-04-30
- DOI
- https://doi.org/10.3892/ijmm.2026.5841
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00