Yb(OTf) <sub>3</sub> -Catalyzed Schmidt-Semipinacol [1,2]-Rearrangements of Bicyclo[1.1.0]butanes with 2-Azidoquinoline 1-Oxides
-catalyzed cascade transformation has been developed, enabling the strain-release driven [1,2]-rearrangement of bicyclo[1.1.0]butanes (BCBs) with 2-azidoquinoline 1-oxides via a Schmidt-type interruption and a subsequent semipinacol rearrangement process. This reaction offers a mild and novel access to highly substituted cyclobutenes in moderate to high yields. The protocol's scalability and the facile derivatization of the products underscore its application potential.
Authors
- Manman Sun (ORCID: https://orcid.org/0000-0003-1126-8777)
- Maozhong Miao (ORCID: https://orcid.org/0000-0001-6777-7189)
- Junying Zhang (ORCID: https://orcid.org/0000-0003-4111-5683)
- Guoxin Yang
- Jing Liu
- Kailiang Ding
Institutions
- Zhejiang Sci-Tech University (CN)
- Advanced Research Institute (US)
- Taizhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.orglett.6c01204
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province