Combinatorial effects of a novel SHV-248 variant, NDM-5, and <i>ompK35</i> deficiency drive high-level cefiderocol resistance in <i>Klebsiella pneumoniae</i>
, risk assessment must evolve to evaluate porin status alongside β-lactamase profiles, as even modestly more efficient enzymes like SHV-248 can become decisive factors within a permissive genetic background.
Authors
- Dandan Wei (ORCID: https://orcid.org/0000-0001-9370-3888)
- Qianbin Dai
- Xinyue Dai (ORCID: https://orcid.org/0000-0003-0570-1810)
- Yuxuan Liu (ORCID: https://orcid.org/0000-0003-4426-9290)
- Hanxu Hong (ORCID: https://orcid.org/0009-0005-0937-429X)
- Liu Y (ORCID: https://orcid.org/0009-0004-3901-1652)
- Chuwen Zhao (ORCID: https://orcid.org/0009-0004-5687-8258)
- Cao Yun
Institutions
- Nanchang University (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1128/spectrum.00026-26
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Nanchang University