Co-occurrence of the tigecycline resistance gene cluster <i>tmexCD3-toprJ1</i> and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived <i>Pseudomonas sediminis</i> isolate
from a child's intestinal tract. Genomic analysis revealed that the gene cluster is present in different hosts and associated with a complex genetic environment. IMPORTANCE: in a complex gene environment. We highlight that these genes have the potential to disseminate across bacterial hosts and may represent a potential reservoir for antimicrobial resistance dissemination.
Authors
- Aoxiao Chen
- Dazhi Jin (ORCID: https://orcid.org/0000-0002-2613-7844)
- Chang Cai (ORCID: https://orcid.org/0000-0002-1122-3045)
- Hongwei Zhou
- Heng Shen
- Rong Zhang
Institutions
- Nanjing Agricultural University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1128/spectrum.03491-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00