RECENT ADVANCES IN BENZIMIDAZOLE DERIVATIVES: CHEMISTRY AND BIOLOGICAL ACTIVITIES

Benzimidazole is a privileged heterocyclic scaffold, which has long been recognized for its significant pharmacological potential. This review focuses on the chemistry, structure, and recent developments in the biological activities of benzimidazole derivatives, which include anticancer, anti-parasitic, antioxidant, anti-fungal, analgesic, and anti-inflammatory activities. The benzimidazole core, which is constructed by linking a benzene ring with an imidazole ring, acts as a platform for structural modifications, which in turn help in designing derivatives with superior activity and selectivity. Structure-activity relationship studies indicate that the type and position of functional groups, especially electron-withdrawing and electron-donating groups, significantly influence their activities. Hybridization with other pharmacophores and the presence of heterocyclic groups enhance their pharmacological activities. Besides, these derivatives show multiple mechanisms of action, which include enzyme inhibition, free radical scavenging, and interference with cell processes. This review emphasizes the significance of structural modifications in optimizing their therapeutic potential and their potential in drug discovery.