Too late to operate? Early surgical assessment in the era of advanced medical therapy for Crohn's disease

BACKGROUND: The expanding availability of advanced medical therapies has profoundly reshaped the management of Crohn's disease. However, an unintended consequence may be the progressive deferral of surgical involvement, with patients often referred only after exposure to multiple treatment lines and with more advanced, high-risk disease. OBJECTIVE: To argue that the key paradigm shift should not be 'early surgery' per se, but rather early surgical assessment as a standard component of multidisciplinary care. METHODS: In this opinion letter, we discuss the implications of delayed surgical involvement and the potential role of integrating surgical assessment earlier in the disease course. RESULTS: Timely surgical involvement may allow better patient selection, improved preoperative optimisation and more appropriate treatment sequencing.

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Publication Details

Journal
Colorectal Disease
Published
2026-04-30
DOI
https://doi.org/10.1111/codi.70469
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Too late to operate? Early surgical assessment in the era of advanced medical therapy for Crohn's disease

Valerio Celentano, Carlo Alberto Manzo
Colorectal Disease
Inflammatory Bowel Disease
article

Too late to operate? Early surgical assessment in the era of advanced medical therapy for Crohn's disease

Valerio Celentano, Carlo Alberto Manzo
article en

Abstract

BACKGROUND: The expanding availability of advanced medical therapies has profoundly reshaped the management of Crohn's disease. However, an unintended consequence may be the progressive deferral of surgical involvement, with patients often referred only after exposure to multiple treatment lines and with more advanced, high-risk disease. OBJECTIVE: To argue that the key paradigm shift should not be 'early surgery' per se, but rather early surgical assessment as a standard component of multidisciplinary care. METHODS: In this opinion letter, we discuss the implications of delayed surgical involvement and the potential role of integrating surgical assessment earlier in the disease course. RESULTS: Timely surgical involvement may allow better patient selection, improved preoperative optimisation and more appropriate treatment sequencing.

Colorectal DiseaseVol. 28(5)
Chelsea and Westminster Hospital NHS Foundation Trust (GB), Aziende Socio Sanitaria Territoriale Rhodense, Imperial College London (GB)
Good health and well-being
Openalex Percentile: Top 13%
Inflammatory Bowel Disease
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