STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology

. Importantly, mice exhibited local and systemic tolerance to the STING agonists. Collectively, these findings suggest a novel STING agonist-based approach for controlling chlamydial infection, which could offer a non-antibiotic, mucosally targeted strategy to reduce the risk of hydrosalpinx in exposed women.

Authors

Q Wang
Chunfu Yang (ORCID: https://orcid.org/0000-0002-3331-0991)
Yidan Gao (ORCID: https://orcid.org/0009-0000-7822-5953)
Yuanshuo Guo
Haoneng Tang
Na Cui
Shuping Hou
Lijuan Jiang
Xuemei Wang
Lingli Tang
Cuixiu Wu

Institutions

Central South University (CN)
Tianjin Medical University General Hospital (CN)
Southern University of Science and Technology (CN)
Guizhou Center for Disease Control and Prevention (CN)
Second Xiangya Hospital of Central South University (CN)

Publication Details

Journal: Infection and Immunity
Published: 2026-04-30
DOI: https://doi.org/10.1128/iai.00761-25
Primary Topic: Reproductive tract infections research
Type: article
Field-Weighted Citation Impact: 0.00

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article

STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology

Q Wang, Chunfu Yang, Yidan Gao, Yuanshuo Guo et al.

Apr 30, 2026

Infection and Immunity

Reproductive tract infections research

article

STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology

Q Wang, Chunfu Yang, Yidan Gao, Yuanshuo Guo, Haoneng Tang, Na Cui, Shuping Hou, Lijuan Jiang, Xuemei Wang, Lingli Tang, Cuixiu Wu

April 30, 2026article en

Abstract

. Importantly, mice exhibited local and systemic tolerance to the STING agonists. Collectively, these findings suggest a novel STING agonist-based approach for controlling chlamydial infection, which could offer a non-antibiotic, mucosally targeted strategy to reduce the risk of hydrosalpinx in exposed women.

Infection and Immunity

Central South University (CN), Tianjin Medical University General Hospital (CN), Southern University of Science and Technology (CN), Guizhou Center for Disease Control and Prevention (CN), Second Xiangya Hospital of Central South University (CN)

Good health and well-being, Gender equality

Openalex Percentile: Top 16%

Reproductive tract infections research

DOI Open Access PDF OpenAlex

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