An Integrated Graphene‐MXene Electrochemical Transistor Array Platform for Accurate Prostate Cancer Diagnosis Using Plasma sEV‐Derived E2F5 Biomarker
exosomes/ml) and detection time within 30 min. Further, dielectrophoresis (DEP) enabled in situ exosome enrichment is integrated, enabling direct analysis of clinical samples without ultracentrifugation. Most importantly, the efficacy of E2F5 as an exosomal protein has been validated for accurate PC diagnosis in all patient cohorts. Multiple features have been extracted from the sensor response and analyzed using an ensemble classification method. Interestingly, the outcomes reveal that the sensor successfully distinguished BPH from HCs with appreciable accuracy of 91.11% and shows similar diagnostic performance with lower grade PC, higher grade PC, and healthy patients.
Authors
- C. RoyChaudhuri (ORCID: https://orcid.org/0000-0001-9619-4150)
- Pritam Das (ORCID: https://orcid.org/0000-0001-6829-7494)
- Sriparna Chatterjee (ORCID: https://orcid.org/0000-0002-3161-1010)
- Nahid Sultana (ORCID: https://orcid.org/0000-0001-9592-0114)
- Laxmidhar Besra
- Sanghamitra Sengupta (ORCID: https://orcid.org/0000-0002-1752-6143)
- Debasree Bishnu (ORCID: https://orcid.org/0000-0002-3628-8005)
- Debansu Sarkar (ORCID: https://orcid.org/0000-0001-8929-0961)
- Ghrutanjali Sahu
- Pooja Sharma
- Piyali Mukherjee
- Isha Goyal
Institutions
- University of Calcutta (IN)
- Kookmin University (KR)
- Central Scientific Instruments Organisation (IN)
- Institute of Post Graduate Medical Education and Research (IN)
- Institute of Minerals and Materials Technology (IN)
- Usha Martin (India) (IN)
- Indian Institute of Engineering Science and Technology, Shibpur (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Small
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1002/smll.73543
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India