Novel Carboline-Based Ferroptosis Inhibitor Ameliorates Acute Liver Injury by Remodeling Phosphatidylcholine
effectively protects against hepatic ischemia-reperfusion injury, as well as ConA- and APAP-induced acute liver injury, demonstrating its potential as a promising therapeutic agent for ferroptosis-related tissue damage.
Authors
- X.C. Li (ORCID: https://orcid.org/0000-0002-5981-2762)
- Shenyou Nie (ORCID: https://orcid.org/0000-0002-7396-8114)
- Hai‐Xin Yuan (ORCID: https://orcid.org/0000-0002-1624-3934)
- Jingsong Zhang
- Y F He
- Yahui Zhao
- Fang Lin
- Lijie Lv
- Hao Chen
- Yijie Xiao
- Biwen Wan
- Mengjie Huang
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Center for Cancer Research (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00720
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Chongqing Municipal Education Commission
- National Key Research and Development Program of China
- Chongqing Municipality Key Research and Development Program of China