Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder
analysis has revealed severe renal disorder in MRL/lpr lupus-prone mice lacking NOX activity compared to wild-type of MRL/lpr. A few clinical reports showed aggravation of inflamed glomerulonephritis in patients with CGD. Taken together, we presumed that a defect of usual NOX-dependent NETosis might be a clue for aggravated renal disorder in CGD. In the present review, we summarize the features of NETosis in CGD and discuss the aggravation mechanism for renal disorder in CGD by referring to previous reports.
Authors
- Masashi Satoh
- Takayuki Imanishi (ORCID: https://orcid.org/0000-0003-1973-4277)
- E Takeuchi (ORCID: https://orcid.org/0000-0001-7623-6261)
- Makoto Otsu (ORCID: https://orcid.org/0000-0002-9769-0217)
- Yasuo Takeuchi (ORCID: https://orcid.org/0000-0003-4193-219X)
- Tadahiro Suenaga (ORCID: https://orcid.org/0009-0006-6802-4844)
- Tetsuya Abe
- Yukihiro Wada
Institutions
- Kitasato University (JP)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-04-20
- DOI
- https://doi.org/10.31083/fbl47594
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00