OMICS-INSPIRED ANALYTICAL STRATEGIES IN PHARMACEUTICAL ANALYSIS: A COMPREHENSIVE REVIEW OF RECENT ADVANCES AND APPLICATIONS

Omics-inspired approaches have emerged as powerful tools in pharmaceutical analysis by enabling a comprehensive and systematic understanding of drugs, biological systems, and disease mechanisms. The term omics encompasses genomics, transcriptomics, proteomics, metabolomics, and lipidomics, which collectively analyze genes, RNA, proteins, metabolites, and lipids on a large scale. Unlike conventional analytical methods, omics technologies provide a holistic view of molecular interactions and biological variability, helping researchers understand complex drug responses and disease progression at the system level. In pharmaceutical analysis, omics approaches play a crucial role in drug discovery, development, and evaluation. They assist in identifying novel drug targets, elucidating mechanisms of action, and discovering reliable biomarkers for diagnosis and therapeutic monitoring.Omics-based studies are also widely used in toxicity assessment and quality control by detecting molecular changes associated with adverse drug reactions and impurities. The integration of advanced analytical techniques such as mass spectrometry, nuclear magnetic resonance spectroscopy, chromatography, and bioinformatics enables high-throughput, sensitive, and accurate data generation and interpretation.