NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension

BACKGROUND: ) drives PH pathogenesis by regulating mitochondrial dynamics. METHODS: interaction was investigated via co-immunoprecipitation and immunofluorescence. An in vivo rescue experiment was performed using intratracheal AAV9-shNDRG2 delivery in SuHx rats. RESULTS: knockdown ameliorated hemodynamic indices, right ventricular hypertrophy, pulmonary vascular remodeling, and exercise capacity in SuHx rats. CONCLUSIONS: NDRG2 drives PH progression by promoting DRP1-mediated mitochondrial fission and vascular remodeling. The NDRG2-DRP1 axis represents a candidate pathway for therapeutic exploration in PH.