High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons
Autoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at inclusion (P = 1.4 × 10-3) and delayed viral clearance (P = .013). Blood AAN-I-IFNs, high viral load and delayed clearance were also independent risk factors for critical COVID-19.
Authors
- Charles‐Hugo Marquette (ORCID: https://orcid.org/0000-0002-0846-9941)
- Antoine Altdorfer (ORCID: https://orcid.org/0000-0003-0120-5190)
- Clément Massonnaud (ORCID: https://orcid.org/0000-0003-0292-9668)
- Mathieu Blot (ORCID: https://orcid.org/0000-0001-6541-2434)
- Paul Bastard (ORCID: https://orcid.org/0000-0002-5926-8437)
- Guillaume Lingas (ORCID: https://orcid.org/0000-0001-8566-6220)
- Nadia Saïdani (ORCID: https://orcid.org/0000-0002-4058-1650)
- Gil Verschelden (ORCID: https://orcid.org/0000-0002-5856-3143)
- Vincent Piriou (ORCID: https://orcid.org/0000-0001-6900-1480)
- Jean-Christophe Navellou
- Alexandre Duvignaud (ORCID: https://orcid.org/0000-0001-7139-2687)
- P Loubet
- Jean‐Philippe Lanoix (ORCID: https://orcid.org/0000-0003-0463-4636)
- Emmanuel Faure (ORCID: https://orcid.org/0000-0003-2618-2706)
- Agathe Delbove (ORCID: https://orcid.org/0000-0003-0170-9508)
- Alexandre Gaymard (ORCID: https://orcid.org/0000-0002-8194-6126)
- Nicolas Terzi (ORCID: https://orcid.org/0000-0003-4036-6245)
- Yoann Zerbib (ORCID: https://orcid.org/0000-0002-9937-6096)
- Vincent Fraipont (ORCID: https://orcid.org/0000-0002-0812-3617)
- Jean Dellamonica (ORCID: https://orcid.org/0000-0002-2681-8260)
- Adrian Gervais (ORCID: https://orcid.org/0000-0002-1083-5787)
- France Mentré (ORCID: https://orcid.org/0000-0002-7045-1275)
- Johan Courjon (ORCID: https://orcid.org/0000-0002-0445-5104)
- J Reignier
- David Bougon
- Sébastien Gibot (ORCID: https://orcid.org/0000-0001-6067-4662)
- Alexander Egle (ORCID: https://orcid.org/0000-0003-0648-4416)
- Richard Greil (ORCID: https://orcid.org/0000-0002-4462-3694)
- Antoine Kimmoun (ORCID: https://orcid.org/0000-0002-5443-2074)
- Lucy Bizien (ORCID: https://orcid.org/0000-0001-9163-9122)
- Bernd Lamprecht (ORCID: https://orcid.org/0000-0003-3365-3449)
- Didier Gruson (ORCID: https://orcid.org/0000-0002-1199-5125)
- Olivier Épaulard (ORCID: https://orcid.org/0000-0001-8282-9522)
- O. Hinschberger (ORCID: https://orcid.org/0000-0003-4841-1637)
- H Esperou
- Maya Hites (ORCID: https://orcid.org/0000-0001-6961-6039)
- Florence Ader (ORCID: https://orcid.org/0000-0002-4778-4338)
- Anne Puel (ORCID: https://orcid.org/0000-0003-2603-0323)
- Céline Robert (ORCID: https://orcid.org/0000-0002-3899-1060)
- Saad Nseir (ORCID: https://orcid.org/0000-0002-7618-0357)
- C. Roger (ORCID: https://orcid.org/0000-0003-2251-2640)
- Henry Lessire
- M Joannidis
- Pierre-Alexandre Roger (ORCID: https://orcid.org/0000-0002-5231-0241)
- Guilhem Wattecamps
- Astrid Marchal (ORCID: https://orcid.org/0000-0003-0648-8126)
- Kada Klouche (ORCID: https://orcid.org/0000-0003-1633-7700)
- Cyrille Chabartier
- Rostane Gaci
- Julien Textoris (ORCID: https://orcid.org/0000-0002-3821-9337)
- Paul Le Turnier (ORCID: https://orcid.org/0000-0002-6164-311X)
- Thibault Kerdiles
- A Makinson
- Joy Mootien
- Julie Bertrand (ORCID: https://orcid.org/0000-0002-6568-1041)
- Violaine Tolsma
- Laurent Argaud
- Pascal Andreu
- V Le Moing
- J Poissy
- F Goehringer
- Charles Cazanave
- F Valour
- Jean Pierre QUENOT
- Benjamin Gaborit
- K Bouiller
- B Lefèvre
- C Delmas
- Florent Wallet
- Aglaé Perrin
- Aurélie Cobat
- Laurent Abel
- Jean-Laurent Casanova
- Maude Bouscambert-Duchamp
- Nathan Peiffer-Smadja
- Jérémie Guedj
- Karine Faure
- Martin Martinot
- Claire Andrejak
- Sylvie Leroy
- the DisCoVeRy Study Group
- François Raffi
- Emmanuel Canet
- Tristan Ferry
- André Cabié
- Jean-Marie Turmel
- Sandrine Couffin-Cadièrgues
- Catherine Chirouze
- Denis Malvy
- Loïc Epelboin
- Jean-Christophe Richard
- Félix Djossou
- Leila Belkhir
- David Boutoille
- Alexandre Boyer
- Thomas Perpoint
- Marie Gousseff
- Lionel Piroth
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Howard Hughes Medical Institute (US)
- Inserm (FR)
- Université Paris Cité (FR)
- Hospital for Sick Children (CA)
- National Institute for Health and Care Research (GB)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Hospital for Sick Children Pediatric Center (US)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier Universitaire Brugmann (BE)
- Institut de Biologie Paris-Seine (FR)
- Hôpital Lariboisière (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Imperial College London (GB)
- Université Paris 1 Panthéon-Sorbonne (FR)
- Rockefeller University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1093/infdis/jiag172
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Howard Hughes Medical Institute
- Fisher Center for Alzheimer's Research Foundation
- St. Giles Foundation
- Meyer Foundation
- JPB Foundation
- Ministry of Health
- Rockefeller University
- Fondation du Souffle
- Institut des maladies génétiques Imagine
- SCOR Corporate Foundation for Science
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Stavros Niarchos Foundation
- Ministère de l'Enseignement Supérieur et de la Recherche
- Université Libre de Bruxelles
- National Institutes of Health
- Horizon 2020
- European Regional Development Fund
- Belgian Health Care Knowledge Centre
- National Center for Advancing Translational Sciences