Demethylase ALKBH4 Inhibits Cell Proliferation via Induction of 5′-tsRNAGlu in Non-Small Cell Lung Cancer
BACKGROUND: , with a particular focus on the role of tsRNA in translational regulation and malignant phenotype formation. METHODS: -test or one-way analysis of variance (ANOVA). RESULTS: to RPL17 interferes with RPL17-rRNA interaction, thereby disrupting the 80S ribosome assembly and global translational efficiency. CONCLUSIONS: and RPL17.
Authors
- Chuanlin Shen
- Yiling Liu (ORCID: https://orcid.org/0000-0002-6872-0106)
- Luyu Shi
- Miaoyan Pu
- Haimei Cheng
- Weijie Ding
- Jiaxin Tian
- Ying Zhang
- Dandan Xu
Institutions
- Northwest University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First Hospital of Xi'an (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-04-20
- DOI
- https://doi.org/10.31083/fbl50109
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Chongqing