<scp>SORBS2</scp> : A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation
(BK) channel drives diabetic vasculopathy. Neurologically, it modulates synaptic remodelling and neuroinflammatory pathways. Functioning as a signalling nexus, SORBS2 interconnects chronic inflammation, oxidative stress and metabolic dysfunction, supporting 'one target for multiple diseases' strategy. Future research requires integration of single-cell omics, Artificial intelligence (AI)-based drug design and epigenetic editing for clinical translation.
Authors
- Qiwei Jia
- Yong Zhang (ORCID: https://orcid.org/0000-0001-8929-3345)
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Journal of Cellular and Molecular Medicine
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1111/jcmm.71160
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00