Abastatins A–C: Cathepsin D‐Inhibitory Depsipeptides From a Marine <i>Okeania</i> sp. Cyanobacterium

values in the picomolar range. In addition, we propose plausible docking poses for abastatins A-C bound to cathepsin D and describe a new structure-activity relationship that can enhance inhibitory potency against this enzyme.

Authors

Nao Tanaka
Yuma Yamaji
Arihiro Iwasaki

Institutions

Chuo University (JP)

Publication Details

Journal: Chemistry - A European Journal
Published: 2026-04-27
DOI: https://doi.org/10.1002/chem.71051
Primary Topic: Protease and Inhibitor Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Naito Foundation
Kato Memorial Bioscience Foundation

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article

Abastatins A–C: Cathepsin D‐Inhibitory Depsipeptides From a Marine Okeania sp. Cyanobacterium

Nao Tanaka, Yuma Yamaji, Arihiro Iwasaki

Apr 27, 2026

Chemistry - A European Journal

Protease and Inhibitor Mechanisms

article

Abastatins A–C: Cathepsin D‐Inhibitory Depsipeptides From a Marine Okeania sp. Cyanobacterium

Nao Tanaka, Yuma Yamaji, Arihiro Iwasaki

April 27, 2026article en

Abstract

Chemistry - A European Journal

Chuo University (JP)

Naito Foundation, Kato Memorial Bioscience Foundation

Life below water

Openalex Percentile: Top 6%

Protease and Inhibitor Mechanisms

DOI Source OpenAlex

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