Negatives about positivity and consistency as conditions for causal inference

Positivity and causal consistency are sometimes presented as general validity requirements. Positivity is not however a general requirement for causal inference, and does not address more demanding practical needs for adequate numbers of observations. Common statistical methods in health and medical research depend on large-sample approximations; yet approximation accuracy is rarely discussed in research reports, even in cases where it has clearly failed. Prioritization by generality and practical importance shifts emphasis to approximation accuracy over positivity, with the latter better cast as a technical requirement for specific types of methods. Meanwhile, consistency mixes requirements for operationally clear definitions of treatments with more general needs for accurate measurement. All statistical methods depend on conceptual precision and measurement accuracy; hence those conditions belong among fundamental requirements for valid inferences, alongside control of selection bias and confounding. When measurement problems are addressed in the basic assumptions of formalizations, consistency can be seen as a definition of the targeted outcome variable in a causal model, rather than a central assumption that mixes separate concerns about construct ambiguity and coarsening.

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Publication Details

Journal
American Journal of Epidemiology
Published
2026-04-25
DOI
https://doi.org/10.1093/aje/kwag093
Primary Topic
Advanced Causal Inference Techniques
Type
article
Field-Weighted Citation Impact
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article

Negatives about positivity and consistency as conditions for causal inference

Sander Greenland, Stephen R Cole
American Journal of Epidemiology
Advanced Causal Inference Techniques
article

Negatives about positivity and consistency as conditions for causal inference

Sander Greenland, Stephen R Cole
article en

Abstract

Positivity and causal consistency are sometimes presented as general validity requirements. Positivity is not however a general requirement for causal inference, and does not address more demanding practical needs for adequate numbers of observations. Common statistical methods in health and medical research depend on large-sample approximations; yet approximation accuracy is rarely discussed in research reports, even in cases where it has clearly failed. Prioritization by generality and practical importance shifts emphasis to approximation accuracy over positivity, with the latter better cast as a technical requirement for specific types of methods. Meanwhile, consistency mixes requirements for operationally clear definitions of treatments with more general needs for accurate measurement. All statistical methods depend on conceptual precision and measurement accuracy; hence those conditions belong among fundamental requirements for valid inferences, alongside control of selection bias and confounding. When measurement problems are addressed in the basic assumptions of formalizations, consistency can be seen as a definition of the targeted outcome variable in a causal model, rather than a central assumption that mixes separate concerns about construct ambiguity and coarsening.

American Journal of Epidemiology
University of North Carolina at Chapel Hill (US), University of California, Los Angeles (US), Department of Health (ZA)
Openalex Percentile: Top 4%
Advanced Causal Inference Techniques
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