Electrochemical Divergent Synthesis of Azetidines via Strain Release of 1‑Azabicyclo[1.1.0]butanes

), and (iv) the kinetic study of the developed methodology. The strategy exhibits broad substrate scope and scalability, making it practical. Installation of generated azetidines into marketed drug motifs, including ibuprofen, naproxen, and olaparib derivative, demonstrates the method's utility. Mechanistic investigations, supported by control experiments, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS), provided key insights into the reaction pathway. This electrochemical approach advances the strain-release chemistry of ABBs and offers a promising platform for future developments.

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Publication Details

Journal
Angewandte Chemie International Edition
Published
2026-04-27
DOI
https://doi.org/10.1002/anie.5707597
Primary Topic
Radical Photochemical Reactions
Type
article
Field-Weighted Citation Impact
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article

Electrochemical Divergent Synthesis of Azetidines via Strain Release of 1‑Azabicyclo[1.1.0]butanes

Sumit K. Rastogi, Prabal Banerjee, Neelam Duhan, Shiv Dutt
Angewandte Chemie International Edition
Radical Photochemical Reactions
article

Electrochemical Divergent Synthesis of Azetidines via Strain Release of 1‑Azabicyclo[1.1.0]butanes

Sumit K. Rastogi, Prabal Banerjee, Neelam Duhan, Shiv Dutt
article en

Abstract

), and (iv) the kinetic study of the developed methodology. The strategy exhibits broad substrate scope and scalability, making it practical. Installation of generated azetidines into marketed drug motifs, including ibuprofen, naproxen, and olaparib derivative, demonstrates the method's utility. Mechanistic investigations, supported by control experiments, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS), provided key insights into the reaction pathway. This electrochemical approach advances the strain-release chemistry of ABBs and offers a promising platform for future developments.

Angewandte Chemie International Edition
Indian Institute of Technology Ropar (IN)
Openalex Percentile: Top 12%
Radical Photochemical Reactions
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