Current practice in reporting internal dosimetry for [177Lu]Lu-DOTATATE therapy: a systematic review

AIM: Lu]Lu-DOTATATE therapy to evaluate whether sufficient data are provided to reproduce methodologies presented. METHODS: Lu]Lu-DOTATATE therapy were identified. Studies were evaluated using a checklist of dosimetry reporting derived from EANM Dosimetry Reporting Guidance and additional fields reflecting recent methodological developments. Compliance with dosimetry reporting guidance was assessed and trends in reporting quality identified. RESULTS: 144 articles were identified, with 57 meeting the inclusion criteria. Many parameters showed good compliance (e.g., 83% reported imaging equipment, 82% image processing and 100% absorbed dose). Some parameters were poorly reported (e.g., 59% reported phantom and calibration measurements, 18% radionuclide calibrator information, 29% listed time-integrated activity coefficients). 25% of papers fully complied with EANM guidance. CONCLUSION: Lu]Lu-DOTATATE. Data acquisition and imaging information are generally well documented, yet key details related to dosimetric calculations remain incompletely reported. To establish reproducible and comparable dosimetry studies, appropriate quality criteria for dosimetry reporting should be further developed.