Stereochemical Terminology in Chiral Drugs: Still Between Confusion and Misinterpretation
The Viewpoint addresses the importance of correct designations of stereochemistry in chiral drugs. Sources of confusion typically arise from merging disparate concepts such as handedness, configuration, and chiroptical properties. This Viewpoint recommends the consistent use of configurational labeling, while avoiding ambiguous and context-dependent nomenclature.
Authors
- Pedro Cintas (ORCID: https://orcid.org/0000-0002-2608-3604)
- Juan García de la Concepción (ORCID: https://orcid.org/0000-0001-6484-9546)
- Anthony J. Burke (ORCID: https://orcid.org/0000-0001-8248-1116)
Institutions
- Instituto de Saúde (BR)
- Faculdade de Medicina do ABC (BR)
- Instituto de Química Orgánica General (ES)
- University of Coimbra (PT)
- Universidad de Extremadura (ES)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00195
- Primary Topic
- Molecular spectroscopy and chirality
- Type
- article
- Field-Weighted Citation Impact
- 0.00