The pattern of fMRI activation with STN DBS reveals symptom-specific networks
= 0.07). Normative connectivity explained variance less consistently. These findings support the use of patient-specific fMRI as a tool for studying the neural mechanisms of DBS and highlight the importance of distributed network engagement in mediating therapeutic benefit.
Authors
- Brendan Santyr (ORCID: https://orcid.org/0000-0003-1782-4527)
- Jürgen Germann (ORCID: https://orcid.org/0000-0003-0995-8226)
- Radhika Madhavan (ORCID: https://orcid.org/0000-0002-9833-437X)
- Ghadh Albuainain
- Artur Vetkas (ORCID: https://orcid.org/0000-0002-4487-432X)
- Afis Ajala (ORCID: https://orcid.org/0000-0002-1763-0274)
- Can Sarica (ORCID: https://orcid.org/0000-0001-8419-7426)
- Mohamad Abbass (ORCID: https://orcid.org/0000-0003-1899-2696)
- Suneil Kalia
- Gavin Elias
- Alfonso Fasano
- Aaron Loh
- Clement Chow
- George M. Ibrahim
- Jianwei Qiu
- Alexandre Boutet
- Andres M. Lozano
- Renato Munhoz
Institutions
- Western University (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Hospital for Sick Children (CA)
- GE Global Research (United States) (US)
- Center for Innovation (US)
- Ontario Brain Institute (CA)
- Krembil Brain Institute
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2026-04-28
- DOI
- https://doi.org/10.1038/s41531-026-01368-x
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Parkinson Canada