Chondroid Syringoma of the Inner Corner of the EyeCase Report

Background and Clinical Significance: Chondroid syringoma is a very rare tumor arising from the sweat glands, with an incidence described in the literature of 0.01% of all primary skin tumors. Case presentation: This paper aims to present the case of a patient treated in our clinic for a large cyst located at the inner corner of the left eye, which appeared two years ago and progressively increased in size. The patient presented for cosmetic reasons and discomfort, especially when wearing glasses. The diagnosis of chondroid syringoma is generally established clinically. The differential diagnosis includes other benign cutaneous lesions (pleomorphic adenoma, lipoma, neurofibroma, a dermoid cyst, dermatofibroma, pleomorphic adenoma of the salivary glands, a sebaceous cyst, or hemangioma) or malignant lesions (basal cell carcinoma, squamous cell carcinoma, or adenocarcinoma). Additional imaging investigations—CT and MRI—are rarely required and would mainly assess the extent of the lesion. Dermoscopy is an early differential diagnostic method, especially for small lesions of 1–3 mm, such as xanthelasma, milia, or basal cell carcinoma. Chondroid syringoma may be treated using minimally invasive methods such as fractional CO2 laser, radiofrequency, or electrocautery, but only when the lesion is superficial and small. For larger and deeper tumors, such as in our case, multiple treatment sessions would be required, increasing the cost, and complete removal would not be guaranteed. Conclusions: The chosen treatment is surgical excision with oncologic margins, followed by histopathological and immunohistochemical examination to prevent recurrence and assess the risk of malignancy.