The Human Gut Microbiome Metabolizes Diverse Bioactive Coumarins via α,β-Unsaturated Lactone Reduction
. Finally, gut microbial metabolites of methoxsalen had diminished cytotoxicity against melanoma cancer cells compared to the parent drug. In summary, the human gut microbiome utilizes a single metabolic pathway to modulate the bioactivities of many coumarins.
Authors
- Isabel M. Chauvin (ORCID: https://orcid.org/0000-0002-6537-2097)
- Matthew T. Henke (ORCID: https://orcid.org/0000-0001-8325-6420)
- Jimmy Orjala (ORCID: https://orcid.org/0000-0002-4420-2048)
- Rasha M. Bashatwah (ORCID: https://orcid.org/0000-0003-2396-9132)
- Andrew P. Riley (ORCID: https://orcid.org/0000-0002-3878-0597)
- Megan J. Jurek
- Joanna E. Burdette (ORCID: https://orcid.org/0000-0002-7271-6847)
- Gabrielle Mingolelli (ORCID: https://orcid.org/0009-0004-6061-2444)
Institutions
- University of Illinois Chicago (US)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-28
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00329
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yarmouk University
- University of Illinois at Chicago
- National Institute of General Medical Sciences
- National Center for Complementary and Alternative Medicine
- National Institute of Neurological Disorders and Stroke
- National Center for Complementary and Integrative Health