Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

The chemistry of imidoyl radicals derived from single‐electron transfer to an isonitrile has been gaining increasing attention, thanks to their multifaceted reactivity. The latter involves the ability of aromatic isonitriles to harvest visible light, reach an electronically excited state, and trigger the formation of open‐shell species from suitable radical precursors. We herein report the synthesis of structurally rich polyaromatic isonitriles, the characterization of their photophysical properties via UV–Vis absorption and fluorescence measurements, along with combined experimental and theoretical studies to evaluate both ground and excited‐state redox properties. Finally, synthetic validation as photoredox catalysts enabled to highlight the best‐performing isonitrile‐based scaffolds, holding promise for further developments in the field.

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Publication Details

Journal
European Journal of Organic Chemistry
Published
2026-04-27
DOI
https://doi.org/10.1002/ejoc.70497
Primary Topic
Radical Photochemical Reactions
Type
article
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article

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

Francesca Brunelli, Greta Donati, Jussara Amato, Cristina Martini et al.
European Journal of Organic Chemistry
Radical Photochemical Reactions
article

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

Francesca Brunelli, Greta Donati, Jussara Amato, Cristina Martini, Carmine Volpe, Mariateresa Giustiniano, Maxime R. Vitale, Camilla Russo, Laurence Grimaud, Andrea Basso
article en

Abstract

The chemistry of imidoyl radicals derived from single‐electron transfer to an isonitrile has been gaining increasing attention, thanks to their multifaceted reactivity. The latter involves the ability of aromatic isonitriles to harvest visible light, reach an electronically excited state, and trigger the formation of open‐shell species from suitable radical precursors. We herein report the synthesis of structurally rich polyaromatic isonitriles, the characterization of their photophysical properties via UV–Vis absorption and fluorescence measurements, along with combined experimental and theoretical studies to evaluate both ground and excited‐state redox properties. Finally, synthetic validation as photoredox catalysts enabled to highlight the best‐performing isonitrile‐based scaffolds, holding promise for further developments in the field.

European Journal of Organic Chemistry
Centre National de la Recherche Scientifique (FR), Chimie ParisTech - PSL (FR), Université Paris Sciences et Lettres (FR), University of Michigan (US), École Normale Supérieure - PSL (FR), Sorbonne Université (FR), Futures Group (United States) (US), Michigan Medicine (US), Industriale Chimica (Italy) (IT), University College London (GB), University of Naples Federico II (IT), University of Genoa (IT)
Openalex Percentile: Top 8%
Radical Photochemical Reactions
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Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts — Francesca Brunelli, Greta Donati, et al. · European Journal of Organic Chemistry (2026) | TGRS Research Map | TGRS