Atypical respiration patterns of kratom alkaloids
Atypical respiration patterns of kratom alkaloidsSafe and effective methods to manage chronic and acute pain remain a significant clinical challenge, calling for novel pharmaceuticals that provide pain relief without the side effects of traditional opioids.Although opioids are the first-line treatment for many types of severe pain, opioid overdose is a leading cause of accidental death in the United States. 1 Traditional opioids such as morphine and oxycodone target the -opioid receptor (OR);
Authors
- Nokomis Ramos‐Gonzalez (ORCID: https://orcid.org/0000-0002-9398-8956)
- Barnali Paul
- Susruta Majumdar (ORCID: https://orcid.org/0000-0002-2931-3823)
- Emily Wells (ORCID: https://orcid.org/0009-0008-3694-0930)
Institutions
- University of Minnesota (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Journal of Pharmacology and Experimental Therapeutics
- Published
- 2026-04-28
- DOI
- https://doi.org/10.1016/j.jpet.2026.104326
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pharmaceutical Research and Manufacturers of America Foundation
- National Institutes of Health
- National Institute on Drug Abuse