Circulating extracellular vesicle-microRNAs (EV-miRNAs) in leukemias and related disorders

Extracellular vesicles (EVs) are nanoparticles released from all cell types and function as a biological tool for cell-to-cell communication or organs located even in remote parts. The numbers and molecular profiles of circulating EVs, including their cargos, change in response to various physical, chemical, inflammatory, and neoplastic stimuli. Therefore, circulating EVs are expected as the next-generation biomarkers or therapeutic targets. MicroRNAs (miRNAs) are short non-coding RNAs enriched with EVs, which are transported to recipient cells to regulate gene expression. Comprehensive analysis of EV-miRNAs is expected to support precision medicine approaches both as biomarker and therapeutic approaches. This mini review focuses on recent advancements in EVs and miRNAs research in leukemias and related disorders.