Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug‐Eluting Stent Implantation

BACKGROUND: loss-of-function alleles. Whether the genotype conveys different prognostic significance between sexes is uncertain. METHODS: genotyping. Patients were classified as rapid/normal metabolizers versus intermediate/poor metabolizers. The primary end point was cardiac death, myocardial infarction, or definite stent thrombosis within 5 years. RESULTS: for interaction=0.049). CONCLUSIONS: loss-of-function allele status was a significant predictor of long-term adverse cardiovascular outcomes in men but not in women, suggesting a sex-specific prognostic difference in patients with acute coronary syndrome undergoing percutaneous coronary intervention. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04734028.

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Publication Details

Journal
Journal of the American Heart Association
Published
2026-04-28
DOI
https://doi.org/10.1161/jaha.125.045981
Primary Topic
Antiplatelet Therapy and Cardiovascular Diseases
Type
article
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article

Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug‐Eluting Stent Implantation

Hyung Joon Joo, Soo Jin Kim, Sang Yeup Lee, J W Suh et al.
Journal of the American Heart Association
Antiplatelet Therapy and Cardiovascular Diseases
article

Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug‐Eluting Stent Implantation

Hyung Joon Joo, Soo Jin Kim, Sang Yeup Lee, J W Suh, Kiyuk Chang, Sung Gyun Ahn, Hyo‐Soo Kim, Moo Hyun Kim, Young‐Hoon Jeong, Young Bin Song, Byeong‐Keuk Kim, Do‐Sun Lim, Ae‐Young Her, Eun‐Seok Shin, Jung Rae Cho
article en

Abstract

BACKGROUND: loss-of-function alleles. Whether the genotype conveys different prognostic significance between sexes is uncertain. METHODS: genotyping. Patients were classified as rapid/normal metabolizers versus intermediate/poor metabolizers. The primary end point was cardiac death, myocardial infarction, or definite stent thrombosis within 5 years. RESULTS: for interaction=0.049). CONCLUSIONS: loss-of-function allele status was a significant predictor of long-term adverse cardiovascular outcomes in men but not in women, suggesting a sex-specific prognostic difference in patients with acute coronary syndrome undergoing percutaneous coronary intervention. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04734028.

Journal of the American Heart AssociationVol. 15(9)
Ulsan College (KR), Hallym University (KR), Kangwon National University (KR), Yonsei University (KR), Korea University (KR), Dong-A University Hospital (KR), Seoul National University Hospital (KR), Seoul National University Bundang Hospital (KR), University of Ulsan (KR), Wonju Severance Christian Hospital (KR), Chung-Ang University (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR), Kosin University (KR)
Openalex Percentile: Top 15%
Antiplatelet Therapy and Cardiovascular Diseases
DOIOpen Access PDFOpenAlex
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