Genetic proxies of GLP1R expression are associated with lower risk of psoriasis and psoriatic arthritis
We used Mendelian randomisation to investigate whether genetic proxies of glucagon-like peptide-1 receptor (GLP-1R) expression are associated with risk of psoriasis and psoriatic arthritis (PsA). Higher GLP-1R expression was associated with reduced susceptibility to psoriasis and PsA, independent of metabolic traits, while no risk-reducing effects were observed for other immune-mediated diseases. These results highlight a disease-specific association between GLP-1 pathway activity and psoriatic disease.
Authors
- D Kim
- Ravi Ramessur (ORCID: https://orcid.org/0000-0003-4599-9455)
- C S Smith (ORCID: https://orcid.org/0000-0003-2677-9991)
- Jake Saklatvala (ORCID: https://orcid.org/0000-0003-0836-4928)
- Daniel B. Shin (ORCID: https://orcid.org/0000-0002-4974-2561)
- Vibeke Videm (ORCID: https://orcid.org/0000-0002-1042-3889)
- Alya GA Arham (ORCID: https://orcid.org/0009-0003-8710-4418)
- Laurent Thomas
- Mari Løset
- Joel M Gelfand
- Mari Hoff
- Michael A Simpson
- Ben M Brumpton
- Bjørn Olav Åsvold
Institutions
- King's College London (GB)
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
- University of Pennsylvania (US)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1093/bjd/ljag163
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00