Genotype and Agronomic Management Interactions Shape the Accumulation of Immunogenic and Toxic Gluten Peptides in Durum Wheat

Currently, there is growing interest in wheat-based products with a reduced digestive impact. We investigated whether agronomic management could modulate the accumulation of immunogenic peptides in durum wheat by using two multifactorial field trials. In the first trial, immunogenic peptide levels were influenced by genotype and by its interaction with nitrogen supply and sowing density, indicating that management effects are highly genotype dependent. In the second trial, the sowing date and fertilization regime affected immunogenic peptide accumulation, with the sowing date being the main driver. Spring sowing reduced the grain yield and increased grain protein and immunogenic peptide levels compared with fall sowing. Overall, these results support the adoption of genotype-specific management strategies to reduce immunogenic peptide accumulation while maintaining a yield in durum wheat.

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Publication Details

Journal
Journal of Agricultural and Food Chemistry
Published
2026-04-28
DOI
https://doi.org/10.1021/acs.jafc.5c16192
Primary Topic
Wheat and Barley Genetics and Pathology
Type
article
Field-Weighted Citation Impact
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article

Genotype and Agronomic Management Interactions Shape the Accumulation of Immunogenic and Toxic Gluten Peptides in Durum Wheat

Sara Graziano, Alessandro Ulrici, Giovanna Visioli, Mariolina Gullì et al.
Journal of Agricultural and Food Chemistry
Wheat and Barley Genetics and Pathology
article

Genotype and Agronomic Management Interactions Shape the Accumulation of Immunogenic and Toxic Gluten Peptides in Durum Wheat

Sara Graziano, Alessandro Ulrici, Giovanna Visioli, Mariolina Gullì, Giovanni Caccialupi, Nicola Pecchioni, Pasquale De Vita, Nelson Marmiroli, Fatma Boukid, Enrico Francia, Barbara Prandi, Arnaldo Dossena, Justyna Milc, Leonardo Cicala
article en

Abstract

Currently, there is growing interest in wheat-based products with a reduced digestive impact. We investigated whether agronomic management could modulate the accumulation of immunogenic peptides in durum wheat by using two multifactorial field trials. In the first trial, immunogenic peptide levels were influenced by genotype and by its interaction with nitrogen supply and sowing density, indicating that management effects are highly genotype dependent. In the second trial, the sowing date and fertilization regime affected immunogenic peptide accumulation, with the sowing date being the main driver. Spring sowing reduced the grain yield and increased grain protein and immunogenic peptide levels compared with fall sowing. Overall, these results support the adoption of genotype-specific management strategies to reduce immunogenic peptide accumulation while maintaining a yield in durum wheat.

Journal of Agricultural and Food ChemistryVol. 74(17)
University of Modena and Reggio Emilia (IT), University of Parma (IT), Cereal Research Centre (IT), Sustainability Institute (ZA), Centre de Recerca en Economia Internacional (ES), Cereal Research (Hungary) (HU)
Università Degli Studi di Modena e Reggio Emila, European Commission, Università degli Studi di Parma, Regione Emilia-Romagna, European Regional Development Fund
Zero hunger
Openalex Percentile: Top 17%
Wheat and Barley Genetics and Pathology
DOIOpen Access PDFOpenAlex
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