Catalyst-Free Three-Component Synthesis of 3-Aminoalkyl Chromones Using Rongalite as a C1 Synthon

Herein, a facile and efficient strategy for one-pot synthesis of 3-aminoalkyl chromones from o-hydroxyaryl enaminones and aromatic amines using inexpensive rongalite as a C1 source has been developed. This three-component protocol enables domino aminomethylation and annulation of o-hydroxyphenyl enaminones without the need for transition metals or oxidants, featuring simple operation, a broad substrate scope, and readily available raw materials, providing a series of 3-aminomethyl chromones in moderate-to-good yields.