An Arginine-Engineered Piezoelectric Conjugated Polymer for Sonodynamic Therapy via Enhanced Cellular Uptake and Electron Transfer-Driven Peroxynitrite Cascade
). This ″piezo-chemical″ cascade amplifies oxidative stress, causing irreversible DNA damage and mitochondrial dysfunction. Consequently, PFT-PArg achieves potent tumor eradication in 4T1 tumor-bearing mice, establishing a high-performance SDT paradigm through the integrated synergy of electron transfer and gas-mediated sensitization.
Authors
- Wanyi Wang (ORCID: https://orcid.org/0000-0001-9482-9968)
- Yue Cao (ORCID: https://orcid.org/0000-0003-3939-2833)
- Zilong Li (ORCID: https://orcid.org/0000-0002-4568-6902)
- Zhijie Fang
- Weiqing Yue
- Xiaomei Lu
- Jie Li (ORCID: https://orcid.org/0000-0001-8841-2373)
- Guohao Wang
- Jinyan Liu
- Liuqi Wang
Institutions
- Nanjing Tech University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2026-04-28
- DOI
- https://doi.org/10.1021/acsami.6c03887
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic Research Program of Jiangsu Province